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Vinorelbine plus cisplatin versus docetaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III randomized trial.
Although the two regimens produced comparable overall survival, the DG regimen had a better toxicity profile and could be used in the first-line setting of advanced NSCLC, especially for patients who cannot tolerate cisplatin.
Vitamin D and Exercise Performance in Professional Soccer Players
It is suggested that vitamin D levels are associated with the ergometric evaluation of muscle strength, as expressed by SJ and CMJ, sprinting capacity, and VO2max in professional soccer players, irrespective the levels of performance.
Discrepancy between Exercise Performance, Body Composition, and Sex Steroid Response after a Six-Week Detraining Period in Professional Soccer Players
The results suggest that the six-week off-season detraining period resulted in a rapid loss of exercise performance adaptations and optimal body composition status, but did not affect sex steroid resting levels.
Front-line Bevacizumab in combination with Oxaliplatin, Leucovorin and 5-Fluorouracil (FOLFOX) in patients with metastatic colorectal cancer: a multicenter phase II study
The combination of FOLFOX4/bevacizumab appears to be highly effective, well tolerated and merits further evaluation in patients with mCRC.
An explosive course of squamous cell penile cancer in an AIDS patient.
The case of a 37-year-old man in whom penile cancer was discovered while he was treated for AIDS 4 years after a human papillomavirus (HSV) infection and died of metastasis within 3 years is reported.
Blockade of platelet alpha2B-adrenergic receptors: a novel antiaggregant mechanism.
Oxaliplatin for Pretreated Patients with Advanced or Metastatic Pancreatic Cancer: A Multicenter Phase II Study
Oxaliplatin as second-line treatment for patients with unresectable pancreatic cancer is well tolerated and associated with improvement of tumor-related symptoms despite its failure to induce objective responses.
Pooled Analysis of Elderly Patients with Non-small Cell Lung Cancer Treated with Front Line Docetaxel/Gemcitabine Regimen: The Hellenic Oncology Research Group Experience
The docetaxel/gemcitabine regimen has a comparable efficacy and tolerance in young (<70 years) and elderly patients and is well tolerated in elderly patients.
Oxaliplatin as First-Line Treatment in Inoperable Biliary Tract Carcinoma
Oxaliplatin is an active agent against biliary tract carcinoma and therefore should be further investigated in combination with other cytotoxic drugs.