Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, E. Speliotes
- BiologyNature
- 11 February 2015
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- J. Lambert, C. Ibrahim-Verbaas, P. Amouyel
- BiologyNature Genetics
- 1 December 2013
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- E. Speliotes, C. Willer, R. Loos
- Biology, Medicine
- 2010
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, T. Frayling
- BiologyNature Genetics
- 8 September 2014
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- B. Voight, L. Scott, M. McCarthy
- BiologyNature Genetics
- 1 July 2010
By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
Hundreds of variants clustered in genomic loci and biological pathways affect human height
- H. Lango Allen, K. Estrada, J. Hirschhorn
- BiologyNature
- 10 August 2010
It is shown that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait, and indicates that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, K. Mohlke
- BiologyNature
- 16 December 2014
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Identification of seven loci affecting mean telomere length and their association with disease
A genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals supports a causal role of telomere-length variation in some age-related diseases.
Genome-wide association study identifies 74 loci associated with educational attainment
- A. Okbay, Jonathan P. Beauchamp, D. Benjamin
- Biology, PsychologyNature
- 31 March 2016
Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
- K. Estrada, U. Styrkársdóttir, F. Rivadeneira
- BiologyNature Genetics
- 9 April 2012
Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways.
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