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Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study
TLDR
The theory of vascular involvement as the etiology of some cases of ISSHL is supported, and the sole predictive factor of poor final hearing is the severity of the initial hearing loss.
Association of the Toll-Like Receptor 4 Gene Asp299Gly Polymorphism With Acute Coronary Events
TLDR
Evidence of an association between the Asp299Gly polymorphism of the human TLR4 receptor and acute coronary syndromes is provided, which confirms the previously reported involvement of TLR 4 in carotid and femoral artery atherosclerosis.
Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide
TLDR
The MGMT protein expression more than MGMT promoter methylation status predicts the response to TMZ in human tumour cell lines.
Von Willebrand Factor and ADAMTS13: A Candidate Couple for Preeclampsia Pathophysiology
TLDR
Preeclampsia is associated with decreased levels of ADAMTS13, independently of VWF, and this decrease is quantitative, occurs early, and seems to be dependent on inflammation.
Abnormal properties of red blood cells suggest a role in the pathophysiology of Gaucher disease.
TLDR
The demonstration that GD RBCs have abnormal rheologic and adhesion properties suggests that they may trigger ischemic events in GD, and possibly phagocytosis by macrophages, leading to the appearance of pathogenic Gaucher cells.
The V249I polymorphism of the CX3CR1 gene is associated with fibrostenotic disease behavior in patients with Crohn's disease
TLDR
In Crohn's disease, V249I CX3CR1 polymorphism is associated with intestinal strictures, particularly in smokers, and this association is independent of CARD15 mutations.
The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations.
TLDR
The results suggest that the CC genotype of the TFPI intron 7 polymorphism is an independent protective factor for venous thromboembolism, an effect probably mediated by increased TFPi levels.
Modulation of tissue factor expression by rapamycin and FK-506 in lipopolysaccharide-stimulated human mononuclear cells and serum-stimulated aortic smooth muscle cells.
TLDR
The aim of this study was to determine the effect of an immunosuppressant macrolide, rapamycin (Sirolimus), on the expression of TF and its inhibitor (TFPI) by monocytic cells and human aortic smooth muscle cells, in comparison with FK-506 and azithromycin.
Combined factor V Leiden (G1691A) and prothrombin (G20210A) genotyping by multiplex real-time polymerase chain reaction using fluorescent resonance energy transfer hybridization probes on the
TLDR
A combined factor V Leiden and prothrombin genotyping method based on multiplex real-time PCR with fluorescent resonance energy transfer (FRET) hybridization probes on the Rotor-Gene 2000 that clearly discriminated among wild-type, homozygous and heterozygous status for the two mutations.
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