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Trichothecenes: From Simple to Complex Mycotoxins
As the world’s population grows, access to a safe food supply will continue to be a global priority. In recent years, the world has experienced an increase in mycotoxin contamination of grains due toExpand
Genes, gene clusters, and biosynthesis of trichothecenes and fumonisins in Fusarium
Trichothecenes and fumonisins are mycotoxins produced by Fusarium, a filamentous fungus that can cause disease in barley, maize, rice, wheat, and some other crop plants. Research on the genetics andExpand
Progesterone implants enhance SIV vaginal transmission and early virus load
Simian immunodeficiency virus (SIV) can cross the intact vaginal epithelium to establish a systemic infection in macaques (mac). Using this SIVmac model, we found that subcutaneous progesteroneExpand
TRI12, a trichothecene efflux pump from Fusarium sporotrichioides: gene isolation and expression in yeast
Abstract Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster. Here we report the complete sequence for TRI12, a gene encodingExpand
Evidence that a secondary metabolic biosynthetic gene cluster has grown by gene relocation during evolution of the filamentous fungus Fusarium
Trichothecenes are terpene‐derived secondary metabolites produced by multiple genera of filamentous fungi, including many plant pathogenic species of Fusarium. These metabolites are of interestExpand
A genetic map of Gibberella zeae (Fusarium graminearum).
We constructed a genetic linkage map of Gibberella zeae (Fusarium graminearum) by crossing complementary nitrate-nonutilizing (nit) mutants of G. zeae strains R-5470 (from Japan) and Z-3639 (fromExpand
Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.
Progesterone and 17 alpha-hydroxyprogesterone (but not other steroids such as testosterone, corticosterone, beta-estradiol, estrone, dehydroepiandrosterone, 20 alpha-hydroxypregnen-3-one,Expand
Tri1 in Fusarium graminearum Encodes a P450 Oxygenase
ABSTRACT Gibberella zeae (asexual state Fusarium graminearum) is a major causal agent of wheat head blight and maize ear rot in North America and is responsible for contamination of grain withExpand
Identification of Loci and Functional Characterization of Trichothecene Biosynthesis Genes in Filamentous Fungi of the Genus Trichoderma †
ABSTRACT Trichothecenes are mycotoxins produced by Trichoderma, Fusarium, and at least four other genera in the fungal order Hypocreales. Fusarium has a trichothecene biosynthetic gene (TRI) clusterExpand
Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia.
The simian immunodeficiency virus (SIV)-rhesus macaque model of heterosexual human immunodeficiency virus transmission consists of atraumatic application of cell-free SIVmac onto the intact vaginalExpand