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Spatiotemporal transcriptome of the human brain
Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete.Expand
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De novo mutations revealed by whole-exome sequencing are strongly associated with autism
Multiple studies have confirmed the contribution of rare de novo copy number variations to the risk for autism spectrum disorders. But whereas de novo single nucleotide variants have been identifiedExpand
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Satb2 Is a Postmitotic Determinant for Upper-Layer Neuron Specification in the Neocortex
Pyramidal neurons of the neocortex can be subdivided into two major groups: deep- (DL) and upper-layer (UL) neurons. Here we report that the expression of the AT-rich DNA-binding protein Satb2Expand
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Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as a candidateExpand
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Transcriptional Landscape of the Prenatal Human Brain
The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the mid-gestational humanExpand
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Contact-dependent inhibition of cortical neurite growth mediated by notch signaling.
The exuberant growth of neurites during development becomes markedly reduced as cortical neurons mature. In vitro studies of neurons from mouse cerebral cortex revealed that contact-mediated NotchExpand
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Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
The lifelong addition of neurons to the hippocampus is a remarkable form of structural plasticity, yet the molecular controls over proliferation, neuronal fate determination, survival, and maturationExpand
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SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons
Neocortical projection neurons exhibit layer-specific molecular profiles and axonal connections. Here we show that the molecular identities of early-born subplate and deep-layer neurons are notExpand
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Whole exome sequencing identifies recessive WDR62 mutations in severe brain malformations
The development of the human cerebral cortex is an orchestrated process involving the generation of neural progenitors in the periventricular germinal zones, cell proliferation characterized byExpand
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Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric disorders. However, understanding the underlying molecular mechanisms remains challenging. RATIONALE To addressExpand
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