N. Yu. Sarycheva

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Cell regulation of Ph(+)cell proliferation and differentiation has been studied ex vivo in various chronic myeloid leukemia (CML) patients. The regulation is provided by alternation of effective stages of proliferation and maturation with inhibition of Ph(+) cell proliferation by accumulating neutrophils under apoptosis blockage. The alternation of stages(More)
The genesp53, mdm2, p21, c-myc,bcr/abl, bcr, bcl2, bax, and gapdh participate in the regulation of cell proliferation and differentiation, apoptosis and cell distribution for the cell cycle ex vivo in the Ph(+)cells of chronic myeloid leukemia containing the Ph chromosome andbcr/abloncogene. Expression of these genes correlates with regulation of cell(More)
The study examined the effect of an analog to N-terminal nociceptin fragment AcOH × Phe-Gly-Gly-Phe-NH2 on the behavior of albino rats. This tetrapeptide (5 μg/kg intraperitoneally) signifi cantly enhanced motor and exploratory activity in mature rats and in 42-day pups and produced opposite effects in 21-day rat pups, which attests to the complex dynamics(More)
The behavior of CBA mice in the hole-board test and elevated plus maze was studied after intraperitoneal injection of skatole leading to destruction of the epithelium in the main olfactory system. Locomotor and exploratory activity and degree of anxieties were low in intact mice. Anosmia was accompanied by an increase in orientation and exploratory(More)
The effect of tuftsin and its tripeptide analog in various concentrations (from 0.001 to 10.0 μg/ml) on phagocytosis and on the intracellular pH is studied in murine peritoneal macrophages. Tuftsin causes a uniform dose-dependent increase of these two parameters in the cells. This effect is maximally pronounced at concentrations of the peptide close to its(More)
85 Nociceptin (nociceptin/orphanin FQ), an endogg enous peptide discovered in 1995 by French researchh ers [1], is akin to enkephalins and endorphins. Simii larly to these compounds, nociceptin is excised from a longer precursor during processing and contains a phenylalanine at position 4. However, the first amino acid in the nociceptin molecule is(More)
It has been shown by the method of probe microfluorimetry of single cells that tuftsin at concentrations of 0.1 and 1.0 μg/mL, increasing the phagocytic activity of murine peritoneal macrophages, causes biphasic changes in the intracellular pH (pHi) over time. First there was a decrease in pHi, reaching the limit in 5 min of incubation. Then, the pHi value(More)
The role of olfaction and the level of olfactory organ development are different in various animal species. The mammals are divided into macrosmatics, which have well-developed olfaction (most species, including rodents), and microsmatics, which have a relatively weak olfaction (seals, whiskered whales, and primates). Olfaction is used by animals for(More)
Fragments of adrenocorticotrophic hormones of the ACTH~7 and ACTH~_~o types are known to stimulate the formation [i] and to delay extinction [6] of conditioned reflexes. A new synthetic heptapeptide, the ACTH~_~o ana lqgMet-Glu-His-Phe-Pro-Gly-Pro which, by modification of the C-terminal structure, evidently becomes more resistant to enzymic degradation(More)
20 Olfaction is vitally important for many mammals, especially rodents. The olfactory analyzer plays an important role in many situations (search for food or sexual partner, exploration of territory, etc). The communication processes that receive and transmit chemical information about environment are associated with olfaction in various types of behavior.(More)