N. Yu. Glazova

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353 Chronic stress is a risk factor of a number of pathol ogies, including depressive disorders [1], with a high degree of comorbidity of depression and anxiety disor ders [2]. In addition, in many patients with these pathologies, disturbance of cognitive functions has been observed [3]. In experiments on animals, it has been demonstrated that, in rats,(More)
Adverse experience during the early postnatal period induces negative alterations in physiological and neurobiological functions, resulting in long-term disorder in animal behavior. The aim of the present work was to study the long-lasting effects of chronic neonatal stress in white rats and to estimate the possibility of their correction using Semax, an(More)
Maternal deprivation in the early postnatal period significantly affects the behavior and development of different animals. Here we studied delayed effects of daily maternal deprivation (5 h/day) on physical development and behavior of white rats during postnatal days 1 to 14. Here we studied the possibility of reducing the negative consequences of(More)
The heptapeptide Semax (MEHFPGP) is an analog of the fragment ACTH(4–10) with long-lasting actions. The aim of the present work was to study the effects of Semax on learning ability and pain sensitivity in white rats given different doses via the intraperitoneal and intranasal routes. The nootropic effects of Semax were studied in a test based on the(More)
A comparative study of nootropic activity of semax (MEHFPGP), an analog of ACTH4–10, and some of its derivatives, in which the N-terminal methionine was modified or substituted with other amino acid residues, was performed. The effect of these peptides on learning of albino rats in tests with positive (food) and negative (pain) reinforcement was studied. In(More)
270 Studies on the physiological effects of ACTH/MSH like peptides, which are now collec tively referred to as melanocortins (MCs), have shown that MCs are involved in the control of memory, atten tion, emotional state, sexual and feeding behaviors, and some other functions [1]. Data accumulated to date allow the conclusion that the ACTH amino acid sequence(More)
Selective serotonin reuptake inhibitors (SSRIs), including fluvoxamine, are widely used to treat depressive disorders in pregnant women. These antidepressants effectively penetrate through the placental barrier, affecting the fetus during the critical phase of neurodevelopment. Some clinical studies have linked prenatal exposure to SSRIs with increased(More)
The effects of Semax on the formation of a conditioned active avoidance reaction were studied in rats using different experimental models. I.p. administration of Semax at a dose of 0.05 mg/kg was found to accelerate the acquisition of a one-way conditioned avoidance reaction in a model of an active pain stimulus avoidance reflex in which the animals had to(More)
The aim of this work was to study the delayed effects of chronic neonatal administration of the selective serotonin reuptake inhibitor fluvoxamine (FA) to white rat pups and to estimate the possibility to correct these effects by treatment with semax. Fluvoxamine was injected intraperitoneally at a dose of 10 mg/kg from postnatal days 1 to 14, and semax was(More)
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