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I ntrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, is a liver disease of pregnancy that complicates 0.7% of pregnancies in the UK. 1 2 ICP causes maternal pruritus and hepatic impairment and can cause fetal death, spontaneous prematurity, and sudden intrauterine death. 3–6 A diagnosis of ICP is made by the demonstration of(More)
BACKGROUND AND AIMS The aim of this study was to investigate the genetic aetiology of intrahepatic cholestasis of pregnancy (ICP) and the impact of known cholestasis genes (BSEP, FIC1, and MDR3) on the development of this disease. PATIENTS AND METHODS Sixty nine Finnish ICP patients were prospectively interviewed for a family history of ICP, and clinical(More)
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