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The synaptic vesicle cycle sustains neurotransmission and keeps pace between exo- and endocytosis in synapses. GTP-binding proteins function as key regulators of this cycle. The large GTPase dynamin is implicated in fission of clathrin-coated vesicles from the presynaptic membrane during endocytosis. The present study addresses the effect of the(More)
To study the development of muscle-specific features during myogenesis, we analysed the ultrastructure and voltage-dependent currents of frog embryonic skeletal myocytes maintained in culture for 10 days. The cells were maintained under culture conditions that prevented cell division, fusion and cell contacts with neuroblasts. The cell surface was estimated(More)
As it was revealed by electron microscopic study, phenazepam (benzodiazepine representative) administered to rats in acute toxic dose caused astrocyte processes swelling mainly in reticular portion of substantia nigra and cerebral areas with high density of GABAergic synapses in initial intoxication stage (one hour after the drug introduction). Following 24(More)
It has been demonstrated in rat experiments that intraperitoneal injection of 100 mg/kg phenazepam immobilizes the animals for one hour, causes long-term diminution of the muscular tonus and disturbed coordination of movements, tachycardia, hypotension, hyperthermia, depression of orientation and exploration motor activity, and disturbance of conditioned(More)
Quantitative changes of sodium and potassium ionic currents were studied in the frog embryonic skeletal myocytes cultures under conditions preventing cell fusion and division. During 7 days of culturing the mean values of the sodium and potassium currents densities were 7- and 1.8-fold increased, resp. In currents clamp records the APs were observed only(More)
A decrease in the amplitude of miniature and evoked end-plate potentials (MEPPs and EPPs) as well as changes in EPP facilitation and depression during frequency stimulation were observed in psychosine-treated m. cutaneous-pectoris of the frog. Electron-microscopic investigation demonstrated severe changes in synaptic Schwann cells embracing motor terminals(More)
A comparative analysis of changes in ultrastructure of neuro-muscular synapses of three types has been studied in the rat diaphragmal muscle at an acute poisoning with chlorophos. A high stability to the damaging action of chlorophos in white muscle fibers has been revealed in comparison with other types. The most essential changes of the ultrastructure(More)
Two methods: labelled Ca45 and Ca++-selective electrode served to assess the Ca++ release during illumination of the rod outer segments in the frog retina. The maximal release (8--10 M Ca++/M bleached rhodopsin) occurred in monovalent cations--free medium (100 MM tris--HCl, 5 mM MgCl2, 5 mM ATP, pH--7.5), when at least 50% of visual pigment was bleached.(More)
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