N. V. Myshlyakova

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The specificity of receptors participating in the interaction with angiotensin II (AT 1--8) fragments, e. g. N-terminal tri-(AT 1--3), C-terminal penta-(AT 4--8), and middle tetrapeptide (at 3--6), was studied in experiments on rat ascending colon which were performed to investigate the influence of a specific angiotensin antagonist, /1-hydantoic acid,(More)
Kinin-like properties of two new peptides NRP-11 and P7 which have structural similarity with neurotensin (NT) and kallidin (K) were investigated. It was found that, unlike NT and K, the new peptides possess reduced myotropic and hypotensive activity. On the other hand, similarly to NT and K, the new peptides exhibited a high histamine-releasing activity in(More)
Cyclic analogs of bradykinin (CBK) and kallidin (CK) have a weak myotropic activity and a marked and prolonged hypotensive effect unlike linear bradykinin (BK) and kallidin (K) which produce a short-term hypotension and considerable contraction of rat uterus smooth muscles. Myotropic effects of BK and CK were significantly inhibited by phentolamine,(More)
A study of the biological activity of six bradykinin and kallidin cycloanalogues has revealed that all of them exhibit prolonged hypotensive activity except the inactive cyclo-(omega-aminododecanoyl-omega-aminododecanoyl-bradykini n) (CADADB) when assayed in anaesthetized rats in vivo. The threshold dose of cyclo-bradykinin (CB) in these experiments was(More)
An important role in the regulation of many processes taking place in man and animals is played by the neurohypophyseal hormones (NHH) vasopressin and oxytocin. However, the broad spectrum of pharmacologic action of NHH (vasopressor, oxytocic, antidiuretic, and other activities) limits their use in medicine. An intensive search is therefore in progress for(More)
A. S. Elina, R. M. Titkova, L. G. Tsy ru l ' n ikova , et al. , Khim. F a r m . Zh., No. 1, 44 (1976). E. N. Pade iskaya , Sb. T r . Vses . NauehnoIss led . Khim. F a r m . Inst . , No. 5, 89 (1976). l~. A. Rudzit , L . I . L i s i t sa , and R. F. Tag! roy , Zh. Mikrobiol . , No. 6, 112 (1973). R. G. Khil ' and T. S. Kupriyanova, Kaz. Med. Zh., No. 2, 66(More)
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