N. V. Gongadze

  • Citations Per Year
Learn More
The therapeutic action of adenocine during cardiac insufficiency (heart failure) caused by ischemic (stenosis) or reperfusion (removal of ligature) injury to the myocardium prevents depletion of ATP, the major energy source for myocytes in the right and left ventricles, and a drop in NAD/NADH ratio. The development of energy shortage during heart failure(More)
An increasing number of studies suggest that current pharmacotherapy used in Alzheimer's disease (AD), in addition to having a symptomatic effect, also may interact with the ongoing neuropathological processes in the brain. The oldest hypothesis explain the cause of the AD is the "cholinergic hypothesis", which states, that AD begins as a deficiency in the(More)
Experimental studies on rats revealed that the newborns growth retardation, caused by long-term treatment with Dexamethasone in the neonatal period, can be prevented by the simultaneous with dexamethasone administration of the nitric oxide donor--L-arginine. This indicates that the mentioned Dexamethasone-induced growth disorder is caused by inhibition of(More)
It is believed that hyperemia in the skin, resulting from applied weak mechanical pressure delays the development of ischemia, and that it is a defensive neurovascular reaction against the local pressure, which can be considered as a critical point in terms of prevention of ischemia and, respectively, the risk for development of bedsores. Taking into(More)
The aim of this review is to provide the molecular evidence as well as the properties and significant role of the platelet activating factor, acetylalkylglycerylic ethers analogs of phosphorylcholines and the alkylphosphocholines, a new class of pharmacophores, in signal transduction processes. These substances are involving in many cellular functions,(More)
Combination of preventive and repeated (after 12 h) intravenous injection of zafirlucast in daily dose of 40 mg/kg to rabbits with epinephrine-induced heart injury essentially decreased the content of leukotriene C(4), but did not prevent the increase of leukotriene B(4) concentration in the blood, though drcreased its content in comparison with the level(More)
Combination of preventive and repeated (after 12 h) injections of zafirlucast in a daily dose of 40 mg/kg to animals with epinephrine-induced heart injury essentially decreased the content of leukotriene C4, but did not prevent the increase of leukotriene B4 content in the blood, though decreased its content in comparison with the level observed 24 h after(More)
In this article review diagnostic value of protein group-lectins for practical oncology are presented. It is indicated, that with some carbohydrate structures lectins revealed the possibility of reversible and selective action and with earlier elaborated methods, which are based on identification of antigen determinants with antibodies, they can(More)
The problem of temperature regulation in the brain tissue in conditions of whole body hyperthermia was investigated in experiments on white rats. The received results revealed that the brain is provided with a highly efficient system for temperature autoregulation against the changes in environmental temperature. According to our data the upper limit of(More)
In the present study we investigated the effects of mixed imidazoline-1 and alpha(2)-adrenoceptor agonist, moxonidine, in glutamate-induced neurotoxicity in frontal cortical cell cultures of rat pups by dye exclusion test. Also, phosphorylated p38 mitogen activated protein kinases (p-p38 MAPK) levels were determined from rat frontal cortical tissue(More)