N. V. Fedina

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Previously, we found that the Noggin family proteins could bind to activin, a member of the TGF-β superfamily, and repress the corresponding signaling cascade. In this work, we characterized a mutant of the Xenopus laevis Noggin2 protein bearing a W203R substitution. This point mutation was shown to enhance the affinity of Noggin to activin, while weakening(More)
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