N. V. Fedina

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Earlier we have revealed the ability of Noggin family proteins to bind a member of the TUF-β superfamily, ActivinB, and to repress the Activin-dependent Smad2 signaling cascade. In the present work we have characterized a mutant of the Xenopus laevis Noggin2, bearing the substitution W203R. We have shown that this point mutation enhances the affinity of(More)
Previously, we found that the Noggin family proteins could bind to activin, a member of the TGF-β superfamily, and repress the corresponding signaling cascade. In this work, we characterized a mutant of the Xenopus laevis Noggin2 protein bearing a W203R substitution. This point mutation was shown to enhance the affinity of Noggin to activin, while weakening(More)
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