N. V. Balashov

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The adrenergic system of the beluga, Huso huso, was studied by glyoxylic acid fluorescence histochemistry, analyses of catecholamine content in various organs and studies of the effects of acetylcholine and adrenaline on isolated strip preparations from blood vessels, spleen, atrium and ventricle. Chromaffin cells were found mainly in the walls of the(More)
Fragments of the calcitonin gene-related neuropeptide's molecule with the amino acid sequence 1-9, 10-20, 15-24, 20-29 and 30-37, were studied. The fragment 20-29 revealed the greatest biological activity: it induced a dose-dependent drop of arterial pressure in i.v. administration, enlarges arterial and venous microvessels when locally applied.
Television microscopic studies have been made of the reaction of mesenterial metarterioles to noradrenalin in newborn, 10- and 30-day rabbits. The results obtained show the existence of postnatal changes in the reactivity of arterioles with a diameter 20-25 mu. Within the period investigated, noradrenalin sensitivity of metarterioles decreases whereas their(More)
Properties of the adenylate cyclase system were simultaneously studied in heart and aorta of rats with renovascular hypertension. Under conditions of the pathology molecular interactions between adrenoreceptors, regulating proteins (N-proteins) and catalytic subunit of the adenylate cyclase system were deteriorated in rat myocardium as well as functions of(More)
After removal of the supper cervical sympathetic ganglion in cats followed by increase of the intraocular pressure from 20 to 32 mm Hg, the outflow of intraocular fluid was sharply enhanced due to lowering tone of tissues of the eye drainage apparatus in the desympathised eye. Noradrenaline was found to reduce sharply by the 4th-5th day in the desympathised(More)
In anesthetized cats, the enhancement of sympathetic activity and increase of the blood pressure in exclusion of afferents (section of vagosympathetic trunks and clamping of common carotid arteries) as well as the disappearance of the activity in enhanced afferentation, were shown to be transient and to disappear within a few minutes-scores of minutes in(More)
In rats with experimental hypertension, mesenteric artery revealed a hypersensitivity to noradrenaline whereas aorta did not differ from normal values of this parameter. The sensitivity of femoral artery was lowered. The microarterioles of hypertensive animals manifested a lower sensitivity to noradrenaline as well. This data suggests that arterial vessels(More)
The sensitivity of smooth muscle cells' adrenoreceptors to noradrenaline (NA) and dopamine (DA) was studied in intact and desympathised arterial microvessels of the rabbit mesentery. The arterioles differed from each other in their sensitivity to catecholamines depending on their diameter. However, in conditions of chemical desympathisation, the sensitivity(More)
Calcitonin gene-related peptide (CGRP), consisting of 37 amino acid residues, is synthesized as the result of alternative processing of the RNA formed on the transcription of the calcitonin gene [1]. The physiological role of CGRP consists in the regulation of the cardiovascular function and the local blood flow, while the peptide exerts an action on the(More)