N Sambamoorthi

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14519 Background: Cox-2 expression is an independent predictor of survival and is over expressed in 89.3% of pts with HRPC. Cox-2 expression has angiogenic and cytoprotective effects. Its suppression could lead to angiogenesis inhibition and increase chemotherapy sensitivity. D in low doses and C are angiogenesis inhibitors. The main objectives were to(More)
18598 Background: The impact of chemotherapy on QOL for pts with HRPC is not well described. Thirty patients(30) participated in a trial of D and C(Kasimis et al, submitted ASCO 2006). The objectives for this companion study were to study QOL outcomes with the FACT instrument including the Prostate subscale(FP) and utility from the EQ5D. METHODS In a(More)
14567 Background: Celecoxib, epirubicin, and estramustine phosphate affect prostate cancer cells through different mechanisms. All three could be synergistic. We studied the effects of this combination on PSA, response, toxicity and survival in pts with HRPC. METHODS Pts after progression from first line taxane-based chemotherapy with rising PSA and(More)
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