N. S. Shastina

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Viral adsorption inhibitors represent new generation of antiviral drugs, which can be applied for the treatment of HIV infection. Given review presents the different classes of HIV entry inhibitors grouped by the processes they are targeted: the binding of viral glycoprotein gp120 with cellular receptor CD4, the following interaction of gp120 with the(More)
A partially protected phosphatidylinositol with a free hydroxyl group in the cyclitol moiety was synthesized by phosphorylation of a tetrasubstituted myo-inositol using the H-phosphonate and phosphoamidite methods. The H-phosphonate method was advantageous for the synthesis of selectively protected monophosphoinositide due to a lesser number of stages. Two(More)
The total synthesis of 1(3)-O-(rac-1,2-dipalmitoylglycerophospho)-4(6)-O- beta-D-glucopyranosyl-sn-myo-inositol was performed. The major stages of the synthetic route are glycosylation of the substituted myo-inositol derivative by the glycosyl fluoride method and creation of the phosphorus moiety of the target glycolipid by means of the H-phosphonate(More)
One of the approaches to enhance the bioavailability of nucleoside reverse transcriptase HIV inhibitors is the design of their prodrugs based on 1,3-diacylglycerols, which may simulate metabolic pathways of natural lipids, thus supporting the efficacy of drug delivery to the target cells. Glycerolipid AZT conjugates with different functional phosphoric(More)
For the purpose of finding effective inhibitors of virus adsorption the series of inositol-containing phospholipid dimer analogues were previously synthesized. In the present work, the antiretroviral activity of these compounds against HIV-1 was demonstrated on the model of cells infected with the virus. The highest effect was found in the case of dimer(More)
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