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Journals and Conferences
A simple and technologically convenient method for the preparation of 1,2,5-trimethylpiperidin-4-one, a key compound in the synthesis of the drug Promedol, was developed.
A new commercially applicable method for the synthesis of the myorelaxant 1,3,5-tris-(2′-diethylbenzylammonioethyl)- 1,3,5-triazine-2,4,6-trione tribromide (isocyuronium bromide) is described.
Oxidative bromination of o-xylene with liquid bromine or hydrobromic acid in aqueous solution in the presence of an alkali-metal bromate as the oxidizing agent was studied. The proposed method allowed the amount of wastes to be reduced while maintaining a high yield of bromo-o-xylene, which is used in the synthesis of vitamin B2.
A preparative-scale method was developed for the production of the analgesic epibatidine, yielding its endo and exo isomers with yields of 9.9% and 8.8% respectively.