N R Guilbaud

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BACKGROUND Release and circulation of tumor DNA could be favored by surgery. No data is available for the effect of laparoscopy on this phenomenon. MATERIAL AND METHODS The aim of this study was to assess the impact of CO2 laparoscopy on circulating tumor DNA. Two xenografts of ovarian cancer were obtained by intraperitoneal inoculation (IP) of IGR-OV1 or(More)
Background: Experimental laparoscopic trials require relevant models of ovarian carcinomatosis. Methods: Female nude rats were inoculated intraperitoneally either with the IGR-OV1 or the NIH:OVCAR-3 human adenocarcinoma cell lines. Serial clinical checks and sacrifices were used to evaluate the rates of tumor take, survival, and patterns of tumor spread.(More)
3196 Background: Paclitaxel (Taxol) is a microtubule binding agent routinely used in cancer treatment. Paclitaxel has been shown to be efficacious in patients with advanced and metastatic breast cancer, as well as in the adjuvant setting in early breast cancer. Numerous preclinical studies using various cancer cell lines have contributed to identify(More)
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