N. P. Sorokina

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Indole de r iva t ives subst i tuted in the 3 posi t ion have a t t rac ted the attention of inves t iga tors for a number of y e a r s . A la rge number of p a p e r s have been devoted to 3-aminoalkyl indoles which include c o m pounds with high pha rmaco log ica l activity. Informat ion about 3-c~-hydroxyacylindoles is m o r e l imited be cause of the(More)
Replacement of the 21-bromine in (II) by an acetoxy group was effected under homogeneous conditions, as described for other steroids in [5], by the action of triethylamine and acetic acid in acetone solution. Reaction time was reduced by half in comparison with literature data [3, 4] where acetoxylation at position 21 was described under heterogeneous(More)
The preparation of 21-phosphoric esters of corticosteroids in a high yield and in a onestage instead of a multistage synthesis [3] became possible due to the appearance of a new phosphorylating agent, pyrophosphoryl chloride [4]. Phosphorus oxychloride and phosphorus pentachloride are not suitable for the phosphorylation of a steroid molecule, since they(More)
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