N. P. Milyutina

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An intraperitoneal injection of an exogenous delta-sleep inducing peptide (DSIP) at a dose of 12 μg/100 g body weight shifted the prooxidant–antioxidant balance of free radical process (FRP) in tissues and erythrocytes of rats: the activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and the(More)
A new method for estimating the genotoxicity of the urban environment is proposed. The method is based on the analysis of the lipid peroxidation (LPO) rate in leaves of woody plants. The mutagenicity of the urban environment was estimated using standard test systems, including plant root meristem (kidney beans germinated in water with suspended particles(More)
In most vertebrates, intermediate products of purine degradation play the role of molecular quenchers of free radicals. Many authors regard these products as a specific level of systemic antioxidant protection. Carbon dioxide and ammonia are terminal products of enzymatic degradation of purines (e.g., adenine) in fish and amphibians. It is well known that(More)
Analysis of polymorphisms of genes encoding antioxidant enzymes SOD1 (G7958A), SOD2 (T58C), CAT (C-262T), and GSTP1 (Ile105Val) in 93 patients with post-traumatic gonarthrosis showed that GSTP1 Ile105Val polymorphism is often associated with heterozygous mutation in catalase gene CAT C-262T. In gonarthrosis, catalase activity in peripheral blood mononuclear(More)
The broad spectrum of regulatory action of arginine is determined by its chemical structure. Several very important metabolites are formed from arginine, and their protective and antioxidant effect is now known [1, 6, 14]. The well-marked cationic properties of the guanidine group of arginine, its ability to form complexes and undergo protonation, or to(More)
Exogenous delta sleep-inducing peptide given i.p. to intact rats at a dose of 12 μg/100 g decreased the levels of diene conjugates and Schiff bases in liver and brain tissues and had no effect on xanthine oxidase activity in these tissues. Cold stress was accompanied by increases in xanthine oxidase activity in rat liver and brain, with a consequent(More)
Administration of artrofoon in combination with SCENAR therapy to patients with localized suppurative peritonitis in the postoperative period considerably reduced plasma MDA level, stabilized ceruloplasmin activity, and increased catalase activity in erythrocytes compared to the corresponding parameters in patients receiving standard treatment in(More)
δ-Sleep-inducing peptide (1 μg/ml) added to erythrocyte suspension from intact rats enhanced quenching of membrane tryptophanyl fluorescence with pyrene and increased the microviscosity of zones of protein-lipid contacts. Microviscosity and polarity of membrane lipid phase remained unchanged. Exogenous δ-sleep-inducing peptide increased the negative surface(More)
The administration of SkQ1 to rats at the dose of 50 nmol/kg for five days significantly increased the mRNA levels of transcription factor Nrf2 and of Nrf2-controlled genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4, whereas changes in the level of mRNA of SOD3 in the cerebral cortex of the rat brain were not significant. This was accompanied by(More)
Introduction of the plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17ß-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%,(More)