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An intraperitoneal injection of an exogenous delta-sleep inducing peptide (DSIP) at a dose of 12 μg/100 g body weight shifted the prooxidant–antioxidant balance of free radical process (FRP) in tissues and erythrocytes of rats: the activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and the(More)
A new method for estimating the genotoxicity of the urban environment is proposed. The method is based on the analysis of the lipid peroxidation (LPO) rate in leaves of woody plants. The mutagenicity of the urban environment was estimated using standard test systems, including plant root meristem (kidney beans germinated in water with suspended particles(More)
In most vertebrates, intermediate products of purine degradation play the role of molecular quenchers of free radicals. Many authors regard these products as a specific level of systemic antioxidant protection. Carbon dioxide and ammonia are terminal products of enzymatic degradation of purines (e.g., adenine) in fish and amphibians. It is well known that(More)
Exposure to long-term hyperbaric conditions presupposes the action of a combination of extremal factors, leading to the development of both adaptive and pathological reactions [3]. One manifestation of the pathological process arising under the influence of a hyperbaric helium-oxygen environment is the development of a "high pressure nervous syndrome,"(More)
We studied the effect of single intravenous injection of perftoran on the intensity of the initial stages of lipid peroxidation and structural and functional characteristics of erythrocyte membranes (cell model). Perftoran slightly activated the initial stages of lipid peroxidation and optimized structural and functional characteristics of erythrocyte(More)
Exogenous delta sleep-inducing peptide given i.p. to intact rats at a dose of 12 μg/100 g decreased the levels of diene conjugates and Schiff bases in liver and brain tissues and had no effect on xanthine oxidase activity in these tissues. Cold stress was accompanied by increases in xanthine oxidase activity in rat liver and brain, with a consequent(More)
Introduction of the plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17ß-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%,(More)
Exposure of rats to cold stress leads to the accumulation of conjugated dienes and Schiff's bases and decreases superoxide dismutase and catalase activities. Plasma levels of extraerythrocytic hemoglobin and iron and the total peroxidase activity increase. This indicates destablization of the erythrocyte plasma membrane in stress. Exogenous δ-sleep-inducing(More)
Administration of artrofoon in combination with SCENAR therapy to patients with localized suppurative peritonitis in the postoperative period considerably reduced plasma MDA level, stabilized ceruloplasmin activity, and increased catalase activity in erythrocytes compared to the corresponding parameters in patients receiving standard treatment in(More)
Analysis of polymorphisms of genes encoding antioxidant enzymes SOD1 (G7958A), SOD2 (T58C), CAT (C-262T), and GSTP1 (Ile105Val) in 93 patients with post-traumatic gonarthrosis showed that GSTP1 Ile105Val polymorphism is often associated with heterozygous mutation in catalase gene CAT C-262T. In gonarthrosis, catalase activity in peripheral blood mononuclear(More)