N Orthen-Gambill

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The present studies tested the hypothesis that histamine blockade stimulates appetite, while increases in histamine levels suppress appetite. Results show that the classical antihistamines cyproheptadine and promethazine both produced significant and long-lasting increases in food intake. Pronounced appetite stimulation was also seen following the(More)
The present study tested the long-term effects of the histamine (H) synthesis inhibitor alpha-fluoromethylhistidine (FMH) on feeding and body weight in rats. FMH (administered via 2-week osmotic minipumps) increased feeding significantly throughout the test period. Body weights were also significantly increased toward the end of the test period.(More)
The present animal studies tested the hypothesis that drug-induced blockade of histamine-1 receptors leads to appetite stimulation. Test agents included the antipsychotic promazine which has very potent antihistaminic effects, as well as the antipsychotic haloperidol and the antidepressant desipramine which both have negligible antihistaminic effects. In(More)
The present study examined the acute effects of the anorectic agents, fenfluramine and amphetamine, on nutrient selection in male Sprague-Dawley rats. One group of animals received continuous access to both granulated sucrose and Purina chow (presented in separate cups), while the other group received only Purina chow. Four doses of fenfluramine (0, 1.5,(More)
Daily caloric intakes and dietary self-selection of the three macronutrients, protein, fat and carbohydrate were examined in female rats following administration of d-amphetamine sulfate (0.0, 0.5, 1.0 and 2.0 mg/kg, IP) or fenfluramine hydrochloride (0.0, 1.5, 3.0 and 6.0 mg/kg, IP). Animals were maintained on ground Purina Chow or one of two(More)
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