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OBJECTIVES Buffered low-dose sublingual transmucosal zolpidem lozenge hemitartrate (ST zolpidem) is being developed for the treatment of middle-of-the-night insomnia. The objective of this double-blind placebo-controlled cross-over study (n = 24) was to evaluate the pharmacokinetics (PK) and daytime-sedative profile of 1.0, 1.75, and 3.5 mg dose of the(More)
BACKGROUND A zolpidem sublingual tablet (ZST) formulation was recently approved by the US Food and Drug Administration to treat middle-of-the-night (MOTN) awakening with difficulty returning to sleep. OBJECTIVE The aim of this study was to compare the zolpidem pharmacokinetic profiles of 3.5-mg ZST and 10-mg immediate-release (IR) oral zolpidem in healthy(More)
STUDY OBJECTIVES To evaluate efficacy and safety of 3.5-mg zolpidem tartrate sublingual tablets (ZST) on latency to sleep onset after middle-of-the-night (MOTN) awakenings in patients with insomnia characterized by difficulty returning to sleep after MOTN awakenings. DESIGN Multicenter randomized, double-blind, placebo-controlled, parallel-group. (More)
The effect of dose and gender on the pharmacokinetics (PK) and pharmacodynamics (PD) of zolpidem after administration of a buffered zolpidem sublingual tablet (ZST; Intermezzo®, Purdue Pharma L.P., Stamford, CT, USA) was evaluated in healthy non-elderly male and female volunteers. Subjects received a single morning dose of ZST (1.0, 1.75, and 3.5 mg) or(More)
Ingesting food can impact the pharmacokinetics of sedative-hypnotic drugs. A buffered zolpidem sublingual tablet (ZST) recently became available for the treatment of middle-of-the-night awakening. In this randomized, open-label, single-site study, the pharmacokinetic profile of ZST was evaluated when administered while fasting and following a standard(More)
BACKGROUND Pharmacokinetic parameters of sedative-hypnotic medications can be influenced by age and gender. OBJECTIVE This study analyzed pharmacokinetic parameters of zolpidem, formulated as a sublingual zolpidem tartrate tablet (ZST; Intermezzo®), in healthy elderly males and females (mean age 72 years) and in non-elderly males and females (34 years).(More)
Many practical applications such as medical image segmentation, object detection, recognition tasks and video surveillance have need for accurate image segmentation techniques. Hence image segmentation is an important technique for image processing which is regarded as first step for image analysis. In this paper an image segmentation technique based on(More)
This paper presents a two-camera-based vision system for image feature selection, tracking of the selected features and the calculation of 3D distance of the selected features. The feature tracking approach is based on minimisation of the sum of squared intensity differences between the past and the current window, which determines whether a current window(More)
OBJECTIVE Evaluate potential gender effects on efficacy and safety of a buffered zolpidem sublingual tablet (ZST) formulation. METHODS Post hoc analysis of the pivotal sleep laboratory and outpatient studies, per gender. RESULTS In the sleep laboratory study, polysomnography-derived latency to persistent sleep after middle-of-the-night was significantly(More)
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