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The retinoblastoma gene, a prototypic tumour-suppressor gene, encodes a nuclear phosphoprotein (Rb). To understand better the role of Rb in development and in tumorigenesis, mice with an insertional mutation in exon 20 of the Rb-1 locus were generated. Homozygous mutants die before the 16th embryonic day with multiple defects. The haematopoietic system is(More)
To assess the functions of the retinoblastoma protein (RB) during normal development, we have analyzed mouse embryos that lack a functional copy of the retinoblastoma gene (genotype: Rb-1 delta 20/Rb-1 delta 20). Our findings demonstrate that RB plays an important role in the regulation of the neuronal cell cycle. In mutant embryos, dividing cells are found(More)
This paper presents the use of the induction motor current to identify and quantify common faults within a two-stage reciprocating compressor. The theoretical basis is studied to understand current signal characteristics when the motor undertakes a varying load under faulty conditions. Although conventional bispectrum representation of current signal allows(More)
Objective: To analyze features and the related factors of myoclonus of 47 patients with probable or possible Creutzfeldt-Jakob disease (CJD). Methods: All patients diagnosed with"suspected CJD" and hospitalized in Xuanwu Hospital from January 2013 to November 2015 were included, and their clinical information and myoclonus features were analyzed. Age,(More)
Objective: To explore the clinical and scalp video electroencephalographic(EEG) characteristics of insula lobe epilepsy identified by intracranial electrode, and to provide some references for early diagnosis and clinical evaluation in patients with insula lobe epilepsy. Methods: A total of 12 patients diagnosed with insula lobe epilepsy identified by(More)
Milk fat globule epidermal growth factor 8 (MFG-E8) is an opsonin involved in the phagocytosis of apoptotic cells. In patients with chronic obstructive pulmonary disease (COPD), apoptotic cell clearance is defective. However, whether aberrant MFG-E8 expression is involved in this defect is unknown. In this study, we examined the expression of MFG-E8 in COPD(More)
This paper proposed a novel integral extension local mean decomposition (IELMD) method, which can be widely applied in wind turbine fault diagnosis. Firstly, the characteristic waveform and its corresponding integral values are calculated. Then, the similar waveform is established according to signal extreme points and their integral values. The similar(More)
– An intense dust storm event over Mongolia and northern China region on March 19-23, 2010 and its transport over the eastern and southern China are addressed using multi-satellite observations and ground-based measurements. A time series of FY-2D China geostationary satellite with temporal resolution of an hour and HYSPLIT model are used to analyze the(More)
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