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The activities of adenylate cyclase (AC) and 5'-nucleotidase (NT) were studied in the limbic (amygdala, hippocampus) and sensorimotor (cortex, striatum) brain structures of three rat groups: control (without training), not well and well learning to perform movements with pushing the operandum. It was found, that after training the activity of AC was(More)
Physiological development, movement activity and cognitive functions of rats subjected to acute normobaric hypoxia (7% O2 during 3 h) at different days of embryogenesis (E14 or E18) were investigated. It was found that prenatal hypoxia led to a delay in physiological development and formation of motor behavior during the 1st month after birth. Differences(More)
The process of learning and memorization of instrumental reaching movements with pressure on an operandum by a preferable forepaw were studied in white rats after ganglioside injections. The coursed of learning in control and ganglioside injected animals were shown to be alike while some ganglioside treated rats demonstrated increased motor activity. After(More)
The aim of the work was the analysis of the changes in a number of labile synaptopodin-positi- ve dendritic spines in parietal cortex and the CA1 field of the hippocampus, which characterize plasticity of intracellular interaction, and of the memorization after short-term repeated immobili- zation stress (daily for 5 minutes, 10 days), both in control rats(More)
The activity of acetylcholinesterase (AChE), 5'-nucleotidase (NT) and adenylate cyclase (AC) were studied in sensomotor cortex and neostriatum (NS) from right and left hemispheres of control and experimental rats, trained to perform food reaching with pushing on operant by preferable forepaw. The levels of summarized bilateral activity of NT as well as of(More)
The role of the neostriatal cholinergic system in the regulation of sensory controlled movements were studied using two behavioral models: 1) maintenance acquired extension of forelimb during proper time (rats) and 2) prolonged conditional flexion of hindlimb (dogs). It was found that injections of carbacholine (Car, 0.03 mkg) into the dorsolateral part of(More)
To study the role of the cholinergic system of the sensorimotor cortex in regulation of different manipulatory movements and locomotion of Wistar rats, the effects of injections of cholinergic drugs (a cholinergic agonist carbachol and an antagonist scopolamine) into the area of forepaw representation in the sensorimotor cortex on motor activity and(More)
Intracortical administration of 10(-4) M batimastat, a specific inhibitor of one of metalloproteinases metabolizing amyloid precursor protein, namely alpha-secretase, to adult rats resulted in a decrease in the number of correct runs in a one-level 8-arm maze down to 92.78 +/- 1.03% of the control values (p < 0.01) already 60 min after an injection. The(More)