N. L. Dembs

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We have investigated the relationships between nitrosourea structure and physicochemical properties and the ability of misonidazole (MISO) to potentiate nitrosourea cytotoxicity in an in vitro model system. EMT-6/Ro tumour cells were exposed in suspension to each of 9 different nitrosourea anti-tumour drugs under hypoxic and aerobic culture conditions.(More)
The effect of incubating KHT-iv tumor cells with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) alone or in simultaneous combination with the radiation sensitizer misonidazole (MISO) was determined for aerobic and hypoxic incubations. Relative to aerobic exposures, the cytotoxicity of BCNU was significantly enhanced when KHT-iv cells were exposed under hypoxic(More)
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