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The histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is frequently dysregulated in cancers, and gain-of-function (GOF) EZH2 mutations have been identified in non-Hodgkin lymphomas. Small-molecule inhibitors against EZH2 demonstrated anti-tumor activity in EZH2-mutated lymphomas and entered clinical trials. Here, we developed models of acquired(More)
We present a variation of an adaptive projection method for computing solutions to the incompressible Navier-Stokes equations with suspended particles. To compute the divergence-free component of the momentum forcing due to the particle drag, we employ an approach which exploits the locality and smoothness of the Laplacian of the projection operator applied(More)
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