N K Shidlovskaia

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The process of long-term preservation of virus antigens outside the main infection focus, which is currently one of the most topical problems, has been studied. The virus antigens were found to be present in the spleen of F1/CBA X C57Black/6 mice during 4-5 weeks following their infection with A/PR/8/34/HIN1 influenza virus. Immunoblotting assay findings(More)
A model of virus-bacterial infection involving A (PR-8/34) influenza virus and group B streptococcus is proposed to demonstrate the cyclic manifestations of fatal synergism of the causative agents correlating with either the cyclic detection of influenza virus antigens in the infection focus on administration of avirulent streptococcal Fos4 strain, or with(More)
The article presents the data on the time-course of formation of ++virus-pecific target-cells in spleens of mice infected with various types of influenza caused by a virulent viral strain and its avirulent ts-mutation. It was demonstrated that these target-cells occurred in all studied patterns of infection. Their formation turned to be of cyclic character,(More)
Animals preexposed to stress developed manifest hyperglycemia in the first 2 days of influenza infection, which was replaced by prolonged hypoglycemia. The status of carbohydrate metabolism normalized no sooner than 3 to 4 weeks after the disease onset, although the acute phase of infection was over by the end of week 2. The changes were evident in the(More)
To study the cell-mediated link of immune response in mice in experimental influenza, both spleen cells obtained from intact mice and infected with the virus in vitro and spleen cells obtained from infected mice on day 6 after infection may equally be used with success as target cells. This opens the possibility of studying the role of virus-specific(More)
The development of the cell-mediated element of immunity in mice in the course of experimental influenza caused by the virulent and avirulent (ts-mutant) variants of influenza A virus was compared. The strains under test were also found to differ in their capacity for reproduction in pulmonary tissue, which could be determined for the mutant variant(More)
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