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To identify novel and potent anticonvulsant ligands, initially 2D and 3D-QSAR models were generated using a series some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole as anticonvulsants. Both the QSAR models yielded significant cross-validated q 2 values of 0.67 and 0.81 and predicted r 2 (pred_r 2) values of 0.66 and 0.83 for 2D(More)
The quantitative structure–activity relationship (QSAR) studies were performed on a series of 42 chalcone derivatives to find out the structural requirements of their antimalarial activities. The multiple linear regression (MLR) and partial least square (PLS) regression methods coupled with various feature selection methods, viz., stepwise (SW), genetic(More)
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