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To examine the significance of anti-catabolism in renal hypertrophy, cellular autophagy was investigated by electron microscopic morphometry in proximal tubular cells (PTCs) of the outer cortex of the rat kidney after the induction of diabetes mellitus by streptozotocin (STZ) and after unilateral nephrectomy. Adult male Sprague-Dawley rats were divided into(More)
Cytoplasmic growth (hypertrophy) presupposes a positive metabolic balance brought about by increased anabolic and/or decreased catabolic processes. Degradation of cytoplasmic components takes place in autophagic vacuoles (AVs) whose volume fraction may be taken as a measure of the relative rate of degradation of cytoplasmic components. Male adult(More)
Two groups of investigators have demonstrated an increase in blood glycogen in diabetics [2, 3]. Treatment with sulphonylureas tended to increase the glycogen content of leukocytes. In ketotic diabetic subjects the blood glycogen was markedly increased. We carried out a series of measurements of the glycogen concentration in diabetic patients of both sexes.(More)
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