N Iu Kotliar

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We have recently described a monoclonal antibody (1F8) that recognizes a form of glucose transporter unique to fat and muscle (James, D. E., Brown, R., Navarro, J., and Pilch, P. F. (1988) Nature 333, 183-185), tissues that respond acutely to insulin by markedly increasing their glucose uptake. Here, we report that rat adipocytes possess two immunologically(More)
Glucose transporter isoform expression was studied in the skeletal muscle-like cell line, C2C12. Northern and Western blot analysis showed that the insulin-responsive muscle/fat glucose transporter isoform, GLUT 4, was expressed in these cells at very low levels, whereas the erythrocyte isoform, GLUT 1, was expressed at readily detectable levels. Insulin(More)
In adipocytes and muscle, insulin stimulates the translocation of glucose transporter proteins from an intracellular vesicle pool to the plasma membrane. To study the molecular basis of this process, we used the anti-GLUT4 antibody 1F8 to isolate intracellular vesicles from rat adipocytes that are enriched in the muscle/fat glucose transporter isoform.(More)
The article presents laboratory results describing influence of hand and arm temperature on capacity of fingers' flexor muscles for dynamic physical work. New means and method for individual protection from local vibration are designed. The authors discuss efficiency of these novelties for exposure of hands to local physical load and vibration.
The authors demonstrated that work of female molders, acquisitors and stacking packers is characterized by physical load, great number of cliched manual movements, intensive inclinations of corpse and constrained working posture. Prolonged exposure to unfavorable occupational factors results in neuromuscular and cardiovascular stress that induces pathologic(More)
We have examined by Northern blot analysis the expression of two members of the glucose transporter family of genes (GLUT-1 and GLUT-2) in regenerating liver and in hepatocytes cultured under various conditions. GLUT-1, although thought to be a growth-associated gene, is not expressed in normal or regenerating liver, whereas GLUT-2, a liver-specific gene,(More)
The examination covered female operators of sewing pickup, engaged into the work at video-displays. The total work load appeared to equal 77.6% and the work at video-display--75.2% of the shift time. Functional state of the vision demonstrated a decrease even after 2 hrs of the work, then stabilized by midpoint of the shift and afterwards lowered by 10-12(More)
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