N. I. Vakhrina

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Previously, among substituted anilides of diethylaminoacetic acid (DEA), substances were found with high antiarrhythmic activity [9], exceeding in strength of action such widely used drugs as lidocaine, trimecaine, and ethmozine [6]. On examining some quantitative relationships between structure and function, it was shown that antiarrhythmic activity was(More)
While studying s tructureactivity relationships for amides of amino acids, the anesthetic and antiaggregational activities of arylamides of diethylaminoacetic acid (DAA) were examined. Anesthetic activity of these compounds was partially qualitatively evaluated in [3-5, 8]. However, the inadequacy of test methods and discrepancies in activity data do not(More)
Our previous analysis [1] of the structure – antiinflammatory activity – toxicity relationship in a series of 1-(3 -chlorobuten-2 -yl)-2-methyl-3-aryl-4(3H)-quinazolinonium perchlorates obtained from N-acetyl-N-(3 -chlorobuten-2 -yl)anthranilic acid arylamides was not complemented by a study of the antiinflammatory properties of the latter compounds. To(More)
Continuing the search for aminoacetanilides with antiarrhythmic activity, we have obtained some derivatives with a fixed substituent (CH 3) in the ortho-position of the benzene ring and variable substituents at the amine nitrogen. The methyl group was chosen as the fixed substituent since when this group was present in a series of substituted(More)
A significant number of papers [i-i0] have been devoted to the study of physicochemical properties and to clarification of the structure--activity dependence in a series of substituted anilides of aminoacetic acids. The configurations of the amide groups of bases and salts, and of the intramolecular hydrogen bonds (IIIB) in the given compounds have been(More)
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