N. I. Musaev

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The p r e sen t pape r gives informat ion showing the complete s t ruc tu re of this g lycoside . On acid hydrolys i s the subs tance spli t into L r h a m n o s e and diosgenin. The e l e m e n t a r y analys is and also the molecu la r weight of the g lycoside found f rom the yield of diosgenin show that it is a monos ide . The compound obtained was methy(More)
A technique for the quantitative estimation of intraperitoneally injected unlabelled cordycepin in the acid soluble pool (ASP) isolated from rat brain tissue has been suggested. It consists of consecutive chromatography of ASP on columns of Dowex 1 X 8, Dihydroxyboryl-SP500 and Sephasorb-HP. As a result, the fraction containing 2'-deoxyriboadenosine and(More)
A study was made of the effect of cordicepin on the biosynthesis of rat brain heterogeneous nuclear RNA (hnRNA) fractions, such as poly(A-)hnRNA, oligo(A+)hnRNA and poly(A+)hnRNA differing in the size of poly(A)-segments. Cordicepin was shown to inhibit the biosynthesis of poly(A+)hnRNA alone. However, small doses of the antibiotic do not virtually inhibit(More)
A procedure for quantitative estimation of cordycepin (3'-deoxyadenosine), a specific inhibitor of post-transcriptional polyadenylation of pre-mRNA and of a metabolite of cordycepin 3'-deoxyATP in rat brain tissue is described. The procedure is based on evaluation of an inhibitory effect on the synthesis of polyA in vitro of total nucleoside and nucleoside(More)
Cordycepin (3'-deoxyadenosine) is a specific inhibitor of post-transcription polyadenylation of RNA [4] and is widely used in experiments on intact [I0, 12] and virus-infected .[7, 8] eukaryote cells. The literature on cordycepin contains various references to the unequal sensitivity of biosynthesis of certain fractions of cytoplasmic nonribosomal and(More)
In rat brain cells low doses of cordycepin (3'-deoxyadenosine) practically do not inhibit biosynthesis of hnRNA with short 3'-terminal poly(A) segments. The same antibiotic doses are sufficient for effective inhibition of biosynthesis of hnRNA containing long poly(A) chains.
A procedure is developed for quantitative estimation of intraperitoneally administered unlabelled cordycepin in acid soluble pool isolated from rat brain tissue. The fraction containing 2'- and 3'-deoxyriboadenosine (cordycepin) in acid soluble pool of rat brain was isolated after consecutive chromatography on columns of Dowex 1 X 8, Dihydroxyboryl-SP 500(More)
A technique for the quantitative estimation of intraperitoneally injected unlabelled cordycepin in an acid-soluble pool (ASP) isolated from rat brain tissue is suggested. It consists in consecutive chromatography of ASP on Dowex 1 X 8, Dihydroxyboryl = SP500 and Sephasorb-HP. The fraction containing 2'-deoxyriboadenosine and 3'-deoxyriboadenosine(More)
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