N. I. Libikova

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In recent years the radioprotective activity of S-2(3-aminopropylamino)ethyl thiophosphate (APAETP) has been actively studied in our country [3, 4] and abroad [9, 13]. This radioprotector belongs to the class of sulfur-containing compounds, but s differs from cystamine, AET, and other analogous preparations in a number of its properties. The purpose of the(More)
Disulfide bis-(beta-dimethyl octyl ammonium ethyl) and some of its analogues were shown to have a radioprotective effect. It is suggested that the mechanism of radioprotective action of quaternary ammonium compounds involves both a temporary inhibition of DNA synthesis in radiosensitive tissues and inhibition of oxidative processes in the organism.
The amino group is shown to be the reaction center that is primarily responsible for the radioprotective effect of the thiazoles under study. A phenyl residue also contributes to the radioprotective effect. The influence of thiazoles on DNA biosynthesis on radiosensitive tissues plays an important role in the biochemical mechanism of their radioprotective(More)
It was shown that different polysaccharides markedly vary in their toxicity, exert a radioprotective effect when administered both 24 h and 1-4 h before irradiation, enhance and prolong the radioprotective action of S-containing radioprotective agents, and inhibit DNA synthesis in bone marrow which, in all appearance, plays a certain role in the mechanism(More)