N. I. Kudryashova

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This paper reviews the chemical and functional aspects of the posttranslational modifications of proteins, which are achieved by the addition of various groups to the side chain of the amino acid residue backbone of proteins. It describes the main prosthetic groups and the interaction of these groups and the apoenzyme in the process of catalysis, using(More)
THe initial B,fl'-dicarbomethoxydiethylmethylamine (II) was produced according to the methods described in the literature on the basis of acrylonitrile [3] or methyl acrylate [3-7]. In contrast to the literature data, the reaction of methyl acrylate with methylamine was conducted in aqueous solution; the yield of II was 63-68%. The sodium enolate of(More)
To determine the biological activity of the compounds, the yeast Saccharomyces cerevisiae (Krasnodar strain) was used. Before the test, the culture was activated by transferring from wort agar to a sterile nutrient medium containing 3 g (NH4)2S04, 2.5 g KH2P0~, 1 g MgS04. 7H20, wort 50 ml, and sucrose 20 g in 1 liter of distilled water. For synchronization,(More)
The paper gives data on the fauna of chigger mites (Thrombiculinae), the ectoparasites of small mammals in Mongolia. The ecological and geographic analysis could reveal the major abiotic and biotic determinants of the spread of the chigger mites and make a map of their potential area.
The synthesis and pharmacological properties of a new taurine amide derivative, N-(l-methyl-2-phenylethyl) aminoethanesulfonic acid isopropylamide hydrochloride (I), are described. Pronounced antiarrhythmic effect of compound I was observed in animals with experimental ventricular arrhythmias (early postocclusive and calcium chloride models). The drug(More)
The react ion was c a r r i e d out in alcoholic solution at r o o m t e m p e r a t u r e for an extended t ime (12-20 days) . The react ion of a roma t i c amines with (VI) at room t e m p e r a t u r e leads to the fo rmat ion of hydroxya lkylamines while c losure to a te t rahydroquinol ine r ing occurs on heating [2]. Compound (II) was obtained by the(More)
Glutamic acid is known as one of the maln stimulating types of neuromediators, participating in the transfer of nerve impulses in the CNS [i0]. However, postsynaptic glutamate receptors have been much less studied than the receptors of other neuromediators, such as, for example, acetylcholine [8] and catecholamines [4, 5]. The lack of hlghly specific(More)
The synthesis of some of the compounds was described earlier: ll-Vl [i], Vll-Xl [2], XII [3], XIV and XV [4]. The dihydrochloride of compound XIII was described in [5]. It was prepared by reduction of the 8-phenylisopropylamide of 4,4'-dinitrodiphenylacetic acid with iron in acetic acid. However, the authors did not isolate the base, and indicated that it(More)
It has been shown previously that the introduction of bulky substituents into the amino group of B-phenylisopropylamine (fenamine, I) causes a change in its pharmacological action [i]. In a development of this work it seemed of interest to investigate analogs of (I) with a more complex aromatic system, in particular benzimidazole. Compounds (II) and (III),(More)