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This paper reviews the chemical and functional aspects of the posttranslational modifications of proteins, which are achieved by the addition of various groups to the side chain of the amino acid residue backbone of proteins. It describes the main prosthetic groups and the interaction of these groups and the apoenzyme in the process of catalysis, using(More)
Acid chlorides (IIIa-me) were obtained by heating the acids with thionyl chloride; in this case, 5-hydroxymethyifuran-2-carboxylic acid gig) reacts with thionyl chloride forming 5-hydroxymethylfuran-2-carboxylic acid (Hie). The corresponding amides (IVa-IVe; see Table 1) are formed by reacting the acid chlorides with fl-phenylisopropylamine. It was noted(More)
The de r iva t ives of N-8 -pheny l i sop ropy l p -aminophenylace tamide , which contain alkyl groups on the a roma t i c amino group, p o s s e s s the p r o p e r t i e s of biological ly act ive p repa ra t ions with sedat ive action. The p r epa ra t i on of de r iva t ives of N ~ p h e n y l i s o p r o p y l p -aminophenylace tamide containing d ia(More)
The causes of arrhythmia are varied and numerous. Arrhythmia includes not only disturbances of the functions of the myoeardium itself as a result of mechanical or organic damages but also various functional, nervous, and neurohumoral disorders [2-5]. The multiplicity of causes of appearance of arrhythmia is responsible for the fact that substances belonging(More)
The react ion was c a r r i e d out in alcoholic solution at r o o m t e m p e r a t u r e for an extended t ime (12-20 days) . The react ion of a roma t i c amines with (VI) at room t e m p e r a t u r e leads to the fo rmat ion of hydroxya lkylamines while c losure to a te t rahydroquinol ine r ing occurs on heating [2]. Compound (II) was obtained by the(More)
It has been shown previously that the introduction of bulky substituents into the amino group of B-phenylisopropylamine (fenamine, I) causes a change in its pharmacological action [i]. In a development of this work it seemed of interest to investigate analogs of (I) with a more complex aromatic system, in particular benzimidazole. Compounds (II) and (III),(More)
Glutamic acid is known as one of the maln stimulating types of neuromediators, participating in the transfer of nerve impulses in the CNS [i0]. However, postsynaptic glutamate receptors have been much less studied than the receptors of other neuromediators, such as, for example, acetylcholine [8] and catecholamines [4, 5]. The lack of hlghly specific(More)
The paper gives data on the fauna of chigger mites (Thrombiculinae), the ectoparasites of small mammals in Mongolia. The ecological and geographic analysis could reveal the major abiotic and biotic determinants of the spread of the chigger mites and make a map of their potential area.
To evaluate the neurotropic activity spectrum, we determined the following forms of activity in experiments on white mice: spasmolytic, on the basis of the ability to inhibit spasms during maximum electroshock [6]; muscle relaxant, using the rotating rod test [7]; analgesic, on the basis of the change in electroshock pain threshold; and hypnosedative, from(More)