N. I. Kochergina

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The action of extracts of different origin on growth of human (Tg33) and mouse (L) cell s t r uc tures was studied. Autogeneic extract f rom Tg33 had a stimulant action and allogeneic and xenogeneic extracts f rom HeLa K-41 and L an inhibitory action on growth of cells of a Tg33 culture. Ext rac ts f rom C3H mouse spleen cells and L cells st imulated growth(More)
Effects of the extracts prepared from tissues of fallopian tubes, uterine fibroid and uterine adenocarcinoma on mitotic activity and amitotic division in culture Tg33 were studied. Extracts with two protein concentrations, 25 and 100 mkg/ml, resp., were used. Differences were found between effects of extracts from malignant tissue and those of(More)
Human intrathymic precursors are characterized by mitogenic reaction on thymic hormone, lacking the cortical and medullar thymic membrane markers (CD3, CD4 and/or CD8) and expressing of the common T-cell CD7 and CD5 antigens. Fraction 1.062 g/cm3 of peripheral white blood cells contains cells with analogous characteristics. The cell fraction of blood from(More)
Interaction of two enteropathogenic strains E. coli O55-K59 and human Hela cells containing O(H) isoantigen was studied. When E. coli strain No. 5789 containing heterologic antigen O(H) was added to HeLa cell culture the cytopathogenic effect with the microbial doses of 2 X 10(10), 2 X 10(5), 2X 10(4) was revealed on the third day of the interaction. A dose(More)
It was shown that exposure of mice AKR and (CBA X C57B1/6)F1 to Bacillus intermedius RNAase and its derivative selectively inactivated by the active centre histidine stimulated T-lymphocyte maturation. With using bone marrow and spleen lymphocytes of congenitally thymus-free mice it was revealed that this effect of RNAase was defined by induction of Thy-1(More)
In 93 persons aged 90 to 103 years old the subpopulation compositon of lymphocytes and the level of thymic serum activity (TSA) was studied. In the presence of polymorbidity the low level of TSA was observed in 81% of examinees, with the quantitative deficiency in the relative and absolute number of CD3+CD8+ T-lymphocytes (62% and 78% respectively) and the(More)
Irradiation of CBA mice elicits a pronounced response of intrathymus and bone marrow precursors of T-lymphocytes (PTL) which is manifested by an increase in a relative content of PTL in the thymus and their transfer from bone marrow to thymus. The estimate of the regenerative potency of the thymus most adequately reflects the cellular events leading to(More)
The content of T-cell precursors is increased in the thymus of AKR/J mice. Thymus also contains cells carrying markers of pre-T (SC-1-antigen) and T-(Thy-1-antigen) cells simultaneously. The level of SC-1+-cells grows just before the lymphoma appearance in the AKR/J thymus. Lymphoma cells express both SC-1 and Thy-1-antigens, i. e. they are a transitional(More)