N I Iarushkina

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The effects of stimulation of periaqueductal gray matter on pain threshold and blood corticosterone level were studied in anesthetized rats. The stimulation resulted in a alteration of analgesia and corticosterone level. Stimuli-induced analgesia was decreased by adrenalectomy. Corticosterone implantation (50 micrograms) in periaqueductal gray matter(More)
The effect of stress on pain threshold and blood corticosteroids was studied in anesthetised rats. The stress stimulation resulted in a parallel changes of analgesia and blood corticosteroids. Stress-induced analgesia were decreased after blocking of the pituitary-adrenocortical system by means of dexamethasone implantation (200 micrograms) in(More)
The role of hypophysis and paraventricular hypothalamic nucleus in inhibition of pituitary-adrenocortical system induced with hydrocortisone in increasing doses (100, 300, 1200 mg/100 g b. w.) was studied in rats. The ACTH secretion induced with pituitrin was only decreased after administration of 1200 mg/100 g b. w. of hydrocortisone, whereas smaller doses(More)
The aim was to study the effect of indometacin (IM) induced gastrointestinal injury on somatic pain sensitivity in awake rats. IM was administered at the ulcerogenic dose (35 mg/kg, s. c.) to fasted (24 h) and fed rats. Somatic pain sensitivity was evaluated using a tail flick test. Latency time was measured under conditions of the formation of gastric(More)
Corticotropin-releasing factor (CRF) participates in development of stress-induced analgesia. Midbrain periaqueductal grey matter (MPAG) is one of crucial structures of the brain antinociceptive system. The aim of the study was to investigate effects of the CRF administration into the MPAG on pain sensitivity in alert rats and contribution of opioid(More)
The role of hypothalamic-pituitary-adrenocortical system (HPAS) in analgesic effect induced by central or systemic corticotrophin-releasing hormone (CRH) was studied on anaesthetized male rats. Blockade of the HPAS functional activity by hydrocortisone in pharmacological dose one week before the experiment was used as approach to investigate the(More)
The mechanisms of effect of adrenocortricotropic hormone on pain sensitivity were studied in anaesthetized Sprague-Dawley male rats. Systemic ACTH administration increased the pain thresholds (from 3 min up to the 30 min after injection) in rats with normal production of hormones. The initial stage of ACTH analgesic effect was fully eliminated by blockade(More)
The aim of the study was to investigate the effect of gastric ulcers on somatic nociception in conscious rats. The formation of kissing gastric ulcers was induced by luminal application of 60% acetic. Somatic pain sensitivity was tested by tail flick latency. Application of acetic acid resulted in gastric ulcer formation, somatic hyperalgesia and the(More)
The effect of hormones of hypothalamic-pituitary-adrenocortical system on pain sensitivity were studied in experiments on awake Sprague-Dawley males rats. Pain sensitivity was tested by tail flick reaction induced by thermal stimuli. Systemic glucocorticoids and ACTH injection increased the tail flick latency. The ACTH-induced analgesic effect was(More)
Corticotropin-releasing factor (CRF) is involved in the regulation of pain sensitivity and can cause an analgesic effect in animals and humans. The aim of the study was to investigate the involvement of CRF1 and CRF2 receptors in CRF-induced analgesic effect (after intraperitoneal injection) on somatic pain sensitivity in conscious rats. Somatic pain(More)