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A total of 1,268 patients admitted to hospital wards were kept under surveillance by one observer throughout their stay in hospital. All drugs given to them and the occurrence of adverse reactions were recorded.Drug reactions were found in 10.2% of the 1,160 patients who received drug therapy. Most reactions were due to known pharmacological actions of the(More)
Predisposing factors were sought in 118 patients who developed adverse drug reactions in hospital. Significantly more patients of 60 years and over, and more women than men, developed adverse drug reactions. Patients with reactions had more drugs before the development of the reaction than patients who did not develop reactions. A previous adverse drug(More)
OBJECTIVE To describe a patient with unusually good outcome of a rare, high-grade lymphoma that often involves the nervous system. DESIGN Case report. SETTING University hospital. CASE A 70-year-old pharmacist first presented with meningoencephalitislike symptoms and 6 months later with acute confusional state followed by complex partial status(More)
Although both Ras1 and Ras2 activate adenylyl cyclase in yeast, a number of differences can be observed regarding their function in the cAMP pathway. To explore the relative contribution of conserved and variable domains in determining these differences, chimeric RAS1-RAS2 or RAS2-RAS1 genes were constructed by swapping the sequences encoding the variable(More)
In a survey of adverse drug reactions in wards of two Belfast hospitals for 52 weeks in 1965-6, 2.9% of 1,268 patients seen were admitted to hospital because of adverse reactions to drugs taken for therapeutic reasons and 2.1% were admitted because of self-poisoning. Patients admitted because of adverse drug reactions were older than those admitted because(More)
Cells with typical cytomegalovirus (CMV) inclusion bodies were found in smears of a pleural effusion from a 51-year-old acquired immunodeficiency syndrome patient. He suffered from severe, generalized CMV infection and Pneumocystis carinii pneumonia complicated by recurrent pneumothorax. CMV infection was proven by a positive immunohistochemical reaction.(More)
At autopsy, massive nonamyloid fibrillar deposits, immunoreactive to IgG and kappa light chain, were found in glomeruli, liver, and bone marrow of a 72-year-old woman. The patient suffered from severe nephrotic syndrome, hepatomegaly and cholestasis, normochromic anemia, and IgG kappa monoclonal gammopathy. Fibrillary glomerulopathies, most often denoted as(More)
The tissues of 16 patients bearing a T-cell lymphoma of angioimmunoblastic lymphadenopathy type (AILD-TCL) were investigated for the distribution of Epstein-Barr virus (EBV) subtypes 1 and 2. EBV-association had been proven in these cases by polymerase chain reaction (PCR) for EBV-DNA, in situ hybridization (ISH) for EBV-encoded small nuclear RNAs (EBER)(More)
In brief: Fourteen healthy and seven overtrained competitive distance runners were studied to investigate the frequency and significance of decreased bone marrow cellularity (BMC) and bone marrow hemosiderin (BMH) and the relationship between BMC, BMH, hemoglobin, and serum ferritin levels. Bone marrow hypocellularity or mild hypocellularity was found in(More)