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Although the kinetics of fetal erythropoiesis and the life span of fetal erythrocytes have not been accurately determined, thus precluding a quantitative appraisal of bilirubin production in the fetus, there is convincing evidence that this pigment is formed during intrauterine life. Supporting this are the presence of bilirubin in meconium (2), in fetal(More)
Fasting in newborn Gunn rats caused an increase in serum bilirubin concentration and in liver bilirubin concentration and specific activity, and a significant stimulation of the heme catabolic enzyme, heme oxygenase, in liver. Treatment with glucagon enhanced conversion of newly formed endogenously prelabeled hepatic heme to bilirubin, with subsequent(More)
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