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The Gene Ontology (GO) Consortium (GOC, http://www.geneontology.org) is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over the past year, the GOC has implemented several processes to increase the quantity, quality and specificity of GO annotations. First, the number of(More)
The annual cost of alcohol-related harm in the UK is estimated to be between £17.7 and £25.1 billion with healthcare costs alone reaching £2.7 billion and the costs of alcohol-fuelled crime and disorder accounting for £7.3 billion each year. The aim of the study was to examine the prevalence of alcohol use disorders (AUD) in prison and probation settings in(More)
In 1995, the National Comprehensive Cancer Network (NCCN) embarked on an ambitious project to develop comprehensive diagnostic and treatment algorithms for the broad spectrum of oncologic diseases and support modalities. To date, 28 NCCN guideline panels have developed guidelines covering an estimated 93% of tumors, and an additional 9 panels have(More)
INTRODUCTION AND AIMS There is a strong association between alcohol and offending behaviour and 25% of police time involves alcohol-related incidents. This pilot study aimed to investigate the feasibility of delivering alcohol screening and brief intervention (ASBI) to individuals arrested for offences linked to drinking behaviour. DESIGN AND METHODS(More)
Clinical practice guidelines are reproducible if two groups of experts, presented with the same evidence and methods, derive similar recommendations. Reproducibility is an essential attribute in justifying the use of clinical practice guidelines to guide and monitor physicians' practices. This article will compare guidelines for the management of advanced(More)
Development of the large, real-time data processing system for the SAFEGUARD ballistic missile defense system has led to many innovations in both hardware and software. The objective of this and the following talks is to impart some of the lessons that we have learned, which we believe will be useful to the data processing community.
The four NCCN Guidelines that follow represent the initial deliberations of an institutionally diverse, multidisciplinary panel comprised of internationally recognized experts. These experts have attempted to address the broad range of clinical decisions that oncologists face as they attempt to manage a patient with a particular tumor. The goal of the NCCN(More)
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