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The 5-HT(3) serotonin receptor plays an important role in regulating communication between cells in the central and peripheral nervous systems. It is the target of many different therapeutic agents and abused drugs. A rapid chemical kinetic method with a time resolution of 10 ms in combination with the whole-cell current-recording technique was employed to(More)
Extragonadal germ cell tumors of the head and neck region account for only 5% of all benign and malignant germ cell tumors. Endodermal sinus tumors (EST) of the head and neck region are rare. We report three patients with EST of head and neck region over a period of 10 years; the primary sites of tumor were orbit, maxillofacial region and retroauricular(More)
Geomorphologic and hydrologic research heavily depends on digital elevation models (DEM) which are currently being prepared from digital contours. The present study examines the use and applicability of freely available global elevation data source (3 arc seconds finished Shuttle Radar Topography Mission (SRTM)) in landform characterisation, geomorphometry,(More)
Multiple myeloma, a disease of the elderly, is extremely rare in those below 30 years of age. Two patients with multiple myeloma diagnosed at 20 years and 18 years are described. Both presented with extradural cord compression, lytic bone lesions and bone marrow plasmacytosis. One patient received combination chemotherapy and radiotherapy and survived for(More)
The gamma-aminobutyric acidA (GABA) receptor belongs to a superfamily of proteins involved in chemical reactions that regulate signal transmission between cells of the nervous system and is the target of some of the agents most frequently used in medicine to control disorders of the central nervous system. In contrast to the nicotinic acetylcholine(More)
Metastasis to the orbit from pancreatic adenocarcinoma is rare. A 38-year-old man with metastatic adenocarcinoma of the right orbit at initial examination is described. Two months later he was diagnosed with a pancreatic primary tumor. The incidence and pattern of orbital metastasis in carcinomas is briefly discussed.
Secondary leukemias occurring after the treatment of childhood malignancies are most often acute nonlymphoblastic leukemias. Only rarely do acute lymphoblastic leukemias (ALL) occur as second malignancies. An 18-year-old boy who developed ALL 4 years after Hodgkin's disease is described and the literature on secondary ALL is reviewed.
Avascular necrosis of bone is a well-described complication of cancer chemotherapy containing corticosteroids, and has been observed in lymphomas and acute lymphoblastic leukemia. Avascular necrosis occurring in association with neuroblastoma has never been reported before. This study reports on a 7-year-old boy with stage IV neuroblastoma developing(More)