N. G. Yamshchikova

  • Citations Per Year
Learn More
A dopamine deficit in the nigrostriatal system is the key neurotransmitter impairment that is responsible for the principal clinical manifestations of Parkinson’s disease. Modern therapeutic methods allow one to alleviate the severity of individual symptoms; however, replacement therapy does not prevent the progression of the neurodegenerative process. For(More)
A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 μmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice(More)
The count of dopamine-containing neurons decreased by 77%, the area of the remaining cells shrank by 75%, and the neuroglia doubled 4 weeks after injection of toxin (6-hydroxydopamine) into the compact part of the substantia nigra of the right cerebral hemisphere of rats, while no changes in the substantia nigra of the left hemisphere were observed. Neurons(More)
The aim of the present work was to study the effects of neurotensin on the behavior of rats with neurotoxic lesions to the serotoninergic structures of the substantia nigra of the brain. Changes in the reproduction of conditioned passive avoidance reactions were analyzed, as were changes in the effects of pain stimulation on the activity of rats in the open(More)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by choreic involuntary movements, decline in cognitive functions, behavioral disturbances, and progressive neuronal death affecting primarily the striatum. The fatal nature of HD makes it important to search for new effective methods of its treatment, which requires(More)
This study addressed the effects of microinjections of neurotensin into the caudate nucleus and substantia nigra on the performance of motor reactions in response to positive and negative conditioned signals, as well as the post-effects of microinjections in subsequent experiments. Neurotensin had positive effects on the extinction of non-reinforced motor(More)
  • 1