N. G. Pozdniakova

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Synaptosomes from the rat brain were used to study the influence of protein kinase inhibitors on the plasma membrane calcium permeability and calcium-dependent α-latrotoxin (LTX)-induced [14C] GABA release. It was shown that stimulated by depolarization with 4-aminopyridine (4-AP) calcium permeability was inhibited by sphingosine. Calcium permeability(More)
alpha-Latrotoxin (LTX) is a presynaptic neurotoxin from black widow spider (Latrodectus mactans tredecimguttatus) venom; it causes massive Ca(2+)-independent neurotransmitter release. The effect of LTX on phosphorylation of synaptosomal proteins was studied including synapsin I, synaptotagmin, and dynamin. Experiments were performed in Ca(2+)-supplemented(More)
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