N. G. Bystrenina

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Diurnal changes in the duration of mitosis were studied by the colchicine method in rats aged 45 days. In adult animals the mean diurnal duration of mitosis in the epithelium of the pancreas and liver and in the epidermis was reduced by almost half compared with that at the age of 7 days. Diurnal changes in the mitotic indices for the tissues studied may be(More)
The duration of mitosis in the acinar cells of the pancreas varied from 1.7 to 2.5 h, in the hepatocytes from 1.3 to 5.2 h, and in the epidermis from 1.5 to 2.9 h. Diurnal changes in the mitotic index in the tissues investigated were due to both changes in the duration of mitosis and differences in the rate at which the cells commenced to divide. The(More)
In the acinar cells of the pancreas of 7-day rats the duration of mitosis varied from 1.7 to 2.5 hours, in the hepatocytes--from 1.3 to 5.2 and in the epidermis--from 1.5 to 2.9 hours. The 24-hour variations in the mitotic index were expressed both by the changes in the duration of mitosis and by unequal rate of the cell entrance into mitosis. The peroid of(More)
To determine the duration of mitosis and the ratecof cell proliferation in animal tissues the colchicine method is widely used. Colchicine and its derivatives, it is considered, only block cell division without affecting the rate of entry of cells into mitosis. However, the question of the preprophase action of colchicine has not been adequately studied. In(More)
A significant decrease in the rate of cell entering into mitosis was discovered in exocrine cells of the pancreas and in liver parenchymal cells of 7-day-old rats after colchamine injections at varying times of day. These data indicate that the colchamine method should not be applied to the assessment of mitosis duration and cell proliferation rates in(More)
Regular diurnal changes in the number of mitoses (MI) and the number of DNA-synthesizing cells (ILN) were demonstrated in the liver, epidermis, and exogenous part of the pancreas of rats aged 7 days. The character of these changes differed in the various tissues. No regular correlation was found between diurnal changes in MI or ILN.
Regular circadian variations in the mitotic index and in the number of cells synthesizing DNA (labelled nuclei index) were shown in the liver, epidermis, and in the exocrine portion of the pancreas in 7-day-old rats. The nature of these changes differed in the tissues under study. No regular correlations between the carcadian variations in these two indices(More)
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