N. F. Abdrashitova

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Immune status of 158 workers exposed to ozone in a maximal permissible concentrations (0.1 mg/ml) for a long time was evaluated using a turbidimetric method. A tendency to decrease in IgA concentration in subjects with longer service was detected. The ranges of IgM and IgG levels were determined, which probably reflect individual differences. The(More)
Effects of naturally occurring and semisynthetic penicillins, cephalosporines, amino-glycosides, tetracyclines, and lincomycin on free-radical oxidation were studied in 4 model systems and in intact Wistar rats. Liver and kidney tissue and blood plasma were examined by chemiluminescence. Antibiotics of all groups in therapeutic concentrations exerted(More)
Concentrations of the ions of calcium, sodium, potassium, chloride-anions and end-products of lipid peroxidation in blood serum of patients with bronchopulmonary pathologies were investigated on a background of prolonged exposure in ozone. Ion homeostasis was found to alter as products of lipid peroxidation accumulated. Suppositions regarding possible(More)
Antibiotic therapy of patients with exacerbation of chronic obstructive bronchitis exposed and not exposed to ozone did not improve oxidative metabolism in neutrophils. Cefazolin, ceftizoxime, and gentamicin normalized functional biocidal reserves of neutrophils, which correlated with pronounced therapeutic effects.
Development of chronic bronchitis in individuals chronically exposed to ozone is associated with complex changes in the lipid peroxidation-antioxidant activity system in erythrocytes characterized by intensification of lipid peroxidation and parallel attenuation of antioxidant activity.
Consideration is given to the place occupied by diseases of respiratory organs in the general structure of morbidity. In many ways, growth in their number has been determined by amplification of anthropogenic factors. This is manifested in emergence of new eco-dependent diseases and syndromes including more difficult course of pulmonary pathology. One of(More)
We studied functional activity of the system responsible for generation of reactive oxygen species by blood neutrophils and involved in pathophysiological mechanisms of bronchopulmonary diseases. Insufficiency of this system can be classified as relative, latent (type I and II), and severe.