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Leptomeningeal metastases (LM) occur in 5-10% of patients with solid tumors and are associated with a dismal prognosis. We describe LM from lung adenocarcinoma harboring a mutation in the epidermal growth factor receptor (EGFR) gene that confers sensitivity to the EGFR tyrosine kinase inhibitors (EGFR-TKIs) erlotinib and gefitinib. The CSF concentration of(More)
In classical TDOA/FDOA emitter location methods, pairs of sensors share the received data to compute the CAF and extract the ML estimates of TDOA/FDOA. The TDOA/FDOA estimates are then transmitted to a common site where they are used to estimate the emitter location. However, the two-stage method is not necessarily optimal because in the first stage of(More)
In emitter geo-location estimation systems, it is well known that the geometry between sensors and the emitter can seriously impact the accuracy of the location estimate. Here we consider a case where a set of sensors is tasked to perform a sequence of location estimates on an emitter as the sensors progress throughout their trajectories. The goal is to(More)