N. Ellerbrake

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We recently described the establishment and the characterization of two rat endometrial adenocarcinoma cell lines which we called RUCA-I and RUCA-II. Despite fairly high estrogen receptor levels neither cell line responded to estradiol in conventional cell culture conditions on plastic and in the presence of serum. A limited hormonal response to the(More)
In vitro studies on endometrial carcinogenesis have been hampered by limited differentiation of the cells in culture. Using the endometrial carcinoma cell lines HEC 1B and its subclone HEC 1B(L), we established and characterized cell culture conditions that preserve a more differentiated state of the tumor cells. Randomly seeded HEC 1B(L) cells, if grown in(More)
We recently established and characterized two rat endometrial adenocarcinoma cell lines which we called RUCA-I and RUCA-II. Despite high estrogen receptor levels neither cell line responded to estradiol in conventional cell culture conditions on plastic and in the presence of charcoal stripped fetal calf serum. We further demonstrated that culturing of(More)
We characterized the receptor of the autocrine motility factor (Int. J.Oncol. 3:801-807, 1993) and found, that tumor cell motility plays an important role not only in vitro, but also in bladder cancer patients (Cancer Res. 54:3120-3123, 1994). We developed in vitro assays which characterize the antimotility efficacy of potential anti-cancer drugs. In an(More)
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