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2-Methyl-6-(phenylethynyl)pyridine (3), a potent noncompetitive mGlu5 receptor antagonist widely used to characterize the pharmacology of mGlu5 receptors, suffers from a number of shortcomings as a therapeutic agent, including off-target activity and poor aqueous solubility. Seeking to improve the properties of 3 led to the synthesis of compound 9, a highly(More)
BACKGROUND Glaucoma is a progressive eye disease and a leading cause of visual disability. Automated assessment of the visual field determines the different stages in the disease process: it would be desirable to link these measurements taken in the clinic with patient's actual function, or establish if patients compensate for their restricted field of view(More)
PURPOSE To compare face recognition performance of glaucomatous patients with age-similar visually healthy people. METHODS Percentage of correctly identified faces in the Cambridge Face Memory Test was assessed in glaucomatous patients (n = 54; mean age = 69) with a range of visual field (VF) defects and visually healthy controls (n = 41; mean age = 67).(More)
PURPOSE Visual search plays an integral role in many daily activities. This study aimed to determine whether patients with glaucoma are slower than visually healthy age-matched individuals when searching for items in computer displayed images. METHODS Forty participants were recruited for the study: 20 patients with a clinical diagnosis of glaucoma and 20(More)
BACKGROUND Glaucoma has been shown to lead to disability in many daily tasks including visual search. This study aims to determine whether the saccadic eye movements of people with glaucoma differ from those of people with normal vision, and to investigate the association between eye movements and impaired visual search. METHODS Forty patients (mean age:(More)
This study tests the hypothesis that patients with bilateral glaucoma exhibit different eye movements compared to normally-sighted people when viewing computer displayed photographs of everyday scenes. Thirty glaucomatous patients and 30 age-related controls with normal vision viewed images on a computer monitor whilst eye movements were simultaneously(More)
Patients with more advanced glaucoma are likely to experience problems with everyday visual tasks such as face recognition. However, some patients still perform well at face recognition despite their visual field (VF) defects. This study investigated whether certain eye movement patterns are associated with better performance in the Cambridge Face Memory(More)
PURPOSE To investigate the relationship between reading speed and eye movements in patients with advanced glaucomatous visual field (VF) defects and age-similar visually healthy people. METHODS Eighteen patients with advanced bilateral VF defects (mean age: 71, standard deviation [SD]: 7 years) and 39 controls (mean age: 67, SD: 8 years) had reading speed(More)
OBJECTIVE To explore patient perception of vision loss in glaucoma and, specifically, to test the hypothesis that patients do not recognize their impairment as a black tunnel effect or as black patches in their field of view. DESIGN Clinic-based cross-sectional study. PARTICIPANTS Fifty patients (age range, 52-82 years) with visual acuity better than(More)