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Unforeseen adverse effects exhibited by drugs contribute heavily to late-phase failure and even withdrawal of marketed drugs. Torsade de pointes (TdP) is one such important adverse effect, which causes cardiac arrhythmia and, in some cases, sudden death, making it crucial for potential drugs to be screened for torsadogenicity. The need to tap the power of(More)
A new probability distribution, the xgamma distribution, is proposed and studied. The distribution is generated as a special finite mixture of exponential and gamma distributions and hence the name proposed. Various mathematical, structural, and survival properties of the xgamma distribution are derived, and it is found that in many cases the xgamma has(More)
The method of Least Square is a technique to point out the best selective line among the corresponding data sequences. In this paper we generalized a virtual structure as well as truthful block diagram of first order adaptive delta sigma modulator. It is shown how the MSE algorithm can be utilized in delta sigma modulation. Simulation result show that the(More)
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