N. Bradley Fox

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Genetic linkage studies place a gene causing early onset familial Alzheimer's disease (FAD) on chromosome 14q24.3 (refs 1–4). Five mutations within the S182 (Presenilin 1: PS–1) gene, which maps to this region, have recently been reported in several early onset FAD kindreds5. We have localized the PS-1 gene to a 75 kb region and present the structure of(More)
Hypoproteinaemia may lead to spuriously high electrolyte values using indirect ion-selective electrodes (ISE) compared to direct ISEs. This study evaluates the impact on electrolyte status assessment of direct compared to indirect ISE sodium and potassium measurements in samples from critically ill patients who have a high prevalence of hypoproteinaemia.(More)
Hepatocellular carcinoma (HCC) develops on the background of chronic hepatitis. Leukocytes found within the HCC microenvironment are implicated as regulators of tumour growth. We show that diethylnitrosamine (DEN)-induced murine HCC is attenuated by antibody-mediated depletion of hepatic neutrophils, the latter stimulating hepatocellular ROS and telomere(More)
The present study determined whether grafts of nerve growth factor-producing fibroblasts alter the expression of beta-amyloid in young or aged nonhuman primates. Aged monkeys serve as an animal model which normally exhibits beta-amyloid-laden plaques. Three young adult (7-12 years of age) and three aged (24-29 years of age) rhesus monkeys received(More)
Murine embryonal carcinoma cells, the pluripotent stem cells of teratocarcinoma were injected simultaneously into caudal and cranial sites on the back of syngeneic recipients in order to determine whether regional anatomical differences affect their take and growth rate and differentiation. The overall tumour take rate was higher in caudal than cranial(More)
We evaluate the hyperpfaffian of a skew-symmetric k-ary function polynomial f of degree k/2 · (n−1). The result is a product of the Vandermonde product and a certain expression involving the coefficients of the polynomial f . The proof utilizes a sign reversing involution on a set of weighted, oriented partitions. When restricting to the classical case when(More)
We continue to explore cyclotomic factors in the descent set polynomial Qn(t), which was introduced by Chebikin, Ehrenborg, Pylyavskyy and Readdy. We obtain large classes of factors of the form Φ2s or Φ4s where s is an odd integer, with many of these being of the form Φ2p where p is a prime. We also show that if Φ2 is a factor of Q2n(t) then it is a double(More)
A common feature of many neuropathies is axon degeneration. While the reasons for degeneration differ greatly, the process of degeneration itself is similar in most cases. Axon degeneration after axotomy is termed ‘Wallerian degeneration,’ whereby injured axons rapidly fragment and disappear after a short period of latency (Waller, 1850). Wallerian(More)
1. The absorption and tissue distribution of radioactivity has been studied in rabbits after application of a cream containing 10 mg of the 3H-labelled 1-(2,4-dichloro-beta-[(p-chlorobenzyl)oxy]phenethyl) imidazole nitrate (econazole nitrate, Pevaryl) to the normal or abraded skins of rabbits. 2. Approximately one-third of the dose was absorbed through the(More)
Emerging evidence in both vertebrates and invertebrates is redefining glia as active and mobile players in synapse formation, maturation and function. However, the molecular mechanisms through which neurons and glia interact with each other to regulate these processes is not well known. My thesis work begins to understand how glia use secreted factors to(More)