Aluminum (Al) compounds are neurotoxic and have been shown to induce experimental neurodegeneration although the mechanism of this effect is unclear. In order to study this neurotoxic effect of Al, we have developed an in vitro model system using Al maltolate and human NT2 cells. Al maltolate at 500 microM caused significant cell death with a 24-h… (More)
Synapse loss and neuronal death are key features of Alzheimer's disease pathology. Disrupted axonal transport of mitochondria is a potential mechanism that could contribute to both. As the major producer of ATP in the cell, transport of mitochondria to the synapse is required for synapse maintenance. However, mitochondria also play an important role in the… (More)
Hepatocellular carcinoma (HCC) develops on the background of chronic hepatitis. Leukocytes found within the HCC microenvironment are implicated as regulators of tumour growth. We show that diethylnitrosamine (DEN)-induced murine HCC is attenuated by antibody-mediated depletion of hepatic neutrophils, the latter stimulating hepatocellular ROS and telomere… (More)
Alzheimer's disease (AD) is characterized by neurofibrillary tangles and extracellular amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding the role of Aβ in the pathogenesis of this neurodegenerative disease. While several studies have focused on the mutations associated with AD, our understanding of the epigenetic… (More)
We continue to explore cyclotomic factors in the descent set polynomial Q n (t), which was introduced by Chebikin, Ehrenborg, Pylyavskyy and Readdy. We obtain large classes of factors of the form Φ 2s or Φ 4s where s is an odd integer, with many of these being of the form Φ 2p where p is a prime. We also show that if Φ 2 is a factor of Q 2n (t) then it is a… (More)
The diagram in Supplementary Fig. 6a illustrating the targeting strategy for the nfkb1 S340A KI allele depicts an unrelated targeting strategy. The correct version of the figure appears below.
Alters the DNA Methylation Status of Cell-fate Genes in an Alzheimer's Disease Model" (2013). Abstract Alzheimer's disease (AD) is characterized by neurofibrillary tangles and extracellular amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding the role of Aβ in the pathogenesis of this neurodegenerative disease. While several… (More)
We evaluate the hyperpfaffian of a skew-symmetric k-ary function polynomial f of degree k/2 · (n − 1). The result is a product of the Vandermonde product and a certain expression involving the coefficients of the polynomial f. The proof utilizes a sign reversing involution on a set of weighted, oriented partitions. When restricting to the classical case… (More)