N A Trusova

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Recent studies support a role of the vascular factor in the development of not only cerebrovascular disease but also Alzheimer's disease (AD). Mechanisms of vascular risk factors involved in the pathogenesis of AD remain poorly studied so far. In a number of studies on the evaluation of the efficacy of antihypertensive drugs, statins, aspirin in patients(More)
AIM To study clinical/neuropsychological and neuroimaging characteristics of Alzheimer's disease in the combination with cerebrovascular disease (CVD). MATERIAL AND METHODS Ninety patients with dementia, including 35 patients with AD, 35 patients with mixed dementia (MD) and 20 patients with vascular dementia, were examined. The character of dementia was(More)
Objective. Mixed dementia (MD), characterized by a combination of Alzheimer's disease (AD) and cerebrovascular disease, is one of the most common and, at the same time, poorly diagnosed forms of dementia in the elderly. The aim of our study was to investigate features of AD with its combination with cerebrovascular disease on the basis of clinical,(More)
NMDA-mediated excitotoxicity considered as a main cause of neuronal death after stroke. Memantine is a non-competitive NMDA-receptor antagonist. This article reviews the recent results of experimental studies on the efficacy of memantine as an add-on to improve the safety of thrombolytic therapy.
AIM To evaluate the validity of the Russian version of the modified Addenbrooke's cognitive examination (ACE-m) for Alzheimer's disease (AD) diagnosis. MATERIAL AND METHODS ACE-m and MMSE, as a comparison scale, were administered to 78 patients including 49 patients with AD and 29 healthy people. RESULTS AND CONCLUSION ACE-m demonstrated the high(More)
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